VX-11e
VX-11e (VTX-11e, Vertex-11e) is a potent, selective, and orally bioavailable ERK inhibitor with IC50 of 17 nM (ERK1) and 15 nM (ERK2), over 200-fold selective over other kinases tested.
| Trivial name | VTX-11e, Vertex-11e |
| Catalog Number | S7709 |
| Molecular Formula | C24H20Cl2FN5O2 |
| CAS# | 896720-20-0 |
| Inchi | InChI=1S/C24H20Cl2FN5O2/c1-13-10-29-24(31-19-6-5-17(27)9-18(19)26)32-22(13)15-8-20(28-11-15)23(34)30-21(12-33)14-3-2-4-16(25)7-14/h2-11,21,28,33H,12H2,1H3,(H,30,34)(H,29,31,32)/t21-/m1/s1 |
| Inchi Key | WUTVMXLIGHTZJC-OAQYLSRUSA-N |
| SMILES | CC1=CN=C(N=C1C2=CNC(=C2)C(=O)NC(CO)C3=CC(=CC=C3)Cl)NC4=C(C=C(C=C4)F)Cl |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/vx-11e.html |
| Additional Information | https://file.selleck.cn/downloads/struct/vx-11e-vtx-11e-vertex-11e-chemical-structure-s7709.gif |