VU 0240551
VU 0240551 is a potent neuronal K-Cl cotransporter KCC2 inhibitor (IC50=560 nM) and is selective versus NKCC1. VU 0240551 also inhibits hERG and L-type Ca2+ channels. VU 0240551 attenuates GABA-induced hyperpolarization of P cells, produces a positive shift in the P cell GABA reversal potential and enhances P cell synaptic transmission.
| Catalog Number | E7694 |
| Molecular Formula | C22H26O4 |
| CAS# | 893990-34-6 |
| Inchi | InChI=1S/C22H26O4/c1-14-15(2)22(26)20(16(3)21(14)25)18(17-10-6-4-7-11-17)12-8-5-9-13-19(23)24/h4,6-7,10-11,18H,5,8-9,12-13H2,1-3H3,(H,23,24) |
| Inchi Key | ZBVKEHDGYSLCCC-UHFFFAOYSA-N |
| SMILES | CC1=C(C(=O)C(=C(C1=O)C)C(CCCCCC(=O)O)C2=CC=CC=C2)C |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/vu-0240551.html |
| Additional Information | https://file.selleck.cn/downloads/struct/e7694-vu-0240551-chemical-structure-tube.png |