PH-064
PH-064 (BIM-46187) is a novel imidazo-pyrazine derivative that inhibits the heterotrimeric G-protein complex effectively. PH-064 (BIM46174) inhibits heterotrimeric G-protein signalling in GPCRsthat mediate cyclic AMP generation (GAs), calcium release (GAq), cancer cell invasion by Wnt-2 frizzled receptors, and high-affinity neurotensin receptors (GAo/i and GAq).
| Trivial name | BIM-46187 |
| Catalog Number | S3451 |
| Molecular Formula | C44H58N8O2S2 |
| CAS# | 892546-37-1 |
| SMILES | NC(CSSCC(N)C(=O)N1CC[N]2C=C(N=C2C1CC3CCCCC3)C4=CC=CC=C4)C(=O)N5CC[N]6C=C(N=C6C5CC7CCCCC7)C8=CC=CC=C8 |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/ph-064.html |
| Additional Information | https://file.selleck.cn/downloads/struct/s3451-ph-064-bim-46187-chemical-structure.png |