SARS-CoV-IN-3 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-3 shows anti-Coronavirus activity with an EC50 of 3.6 μM in Vero cells. SARS-CoV-IN-3 inhibits the 3D7 and W2 strains of P. falciparum with IC50s of 11.7 and 20.4 nM; and IC90s of 29.19 and 56 nM; respectively. SARS-CoV-IN-3 reduces HIV-1-induced cytopathic effect with an EC50 of 10 μM in MT-4 cells.IC50 & Target:EC50: 3.6 μM (SARS-CoV, in Vero cells)
IC50: 11.7 nM (3D7 P. falciparum), 20.4 nM (W2 P. falciparum)
IC90: 29.19 nM (3D7 P. falciparum), 56 nM (W2 P. falciparum)In Vitro:SARS-CoV-IN-3 (Compound 4) inhibits in vitro growth of Plasmodium falciparum far better than Chloroquine (CQ) .