CCT128930

CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM in a cell-free assay, 28-fold greater selectivity for Akt2 than the closely related PKA kinase. CCT128930 induces cell cycle arrest, DNA damage, and autophagy independent of Akt inhibition. High dose of CCT128930 triggers cell apoptosis in HepG2 cells.

Price Not Available 10mM/1mL CCT128930 Supplier Page
Trivial name N/A
Catalog Number S2635
Molecular Formula C18H20ClN5
CAS# 885499-61-6
Inchi InChI=1S/C18H20ClN5/c19-14-3-1-13(2-4-14)11-18(20)6-9-24(10-7-18)17-15-5-8-21-16(15)22-12-23-17/h1-5,8,12H,6-7,9-11,20H2,(H,21,22,23)
Inchi Key RZIDZIGAXXNODG-UHFFFAOYSA-N
SMILES C1CN(CCC1(CC2=CC=C(C=C2)Cl)N)C3=NC=NC4=C3C=CN4
Size 10mM/1mL
Supplier Page http://www.selleckchem.com/products/cct128930.html
Additional Information https://file.selleck.cn/downloads/struct/CCT128930-Chemical-structure-s2635.gif