AMG-47a
AMG-47a is a potent, nonselective inhibitor of Lck kinase with IC50 of 3.4 uM and it also inhibits T cell proliferation. AMG-47a exhibit anti-inflammatory activity (ED50) of 11 mg/kg in the anti-CD3-induced production of interleukin-2 (IL-2) in mice.
| Trivial name | N/A |
| Catalog Number | S2213 |
| Molecular Formula | C29H28F3N5O2 |
| CAS# | 882663-88-9 |
| Inchi | InChI=1S/C29H28F3N5O2/c1-19-5-6-21(27(38)35-24-4-2-3-23(17-24)29(30,31)32)16-25(19)20-7-8-26-22(15-20)18-34-28(36-26)33-9-10-37-11-13-39-14-12-37/h2-8,15-18H,9-14H2,1H3,(H,35,38)(H,33,34,36) |
| Inchi Key | DVRSTRMZTAPMKO-UHFFFAOYSA-N |
| SMILES | CC1=C(C=C(C=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)C3=CC4=CN=C(N=C4C=C3)NCCN5CCOCC5 |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/amg-47a.html |
| Additional Information | https://file.selleck.cn/downloads/struct/amg-47a-chemical-structure-s2213.gif |