Vonoprazan
Vonoprazan (TAK-438 free base), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. It also inhibits H⁺, K⁺-ATPase activity in porcine gastric microsomes with an IC50 of 19 nM at pH 6.5. Vonoprazan is selected as a drug candidate for the treatment of gastroesophageal reflux disease (GERD), peptic ulcers, and other acid-related disorders.
| Trivial name | TAK-438 free base |
| Catalog Number | E7004 |
| Molecular Formula | C16H16ClN3O3S |
| CAS# | 881681-00-1 |
| Inchi | InChI=1S/C16H16ClN3O3S/c1-9-5-3-4-6-14(9)20-10(2)19-13-8-12(17)15(24(18,22)23)7-11(13)16(20)21/h3-8,10,19H,1-2H3,(H2,18,22,23) |
| Inchi Key | AQCHWTWZEMGIFD-UHFFFAOYSA-N |
| SMILES | CC1NC2=CC(=C(C=C2C(=O)N1C3=CC=CC=C3C)S(=O)(=O)N)Cl |
| Size | 50mg |
| Supplier Page | http://www.selleckchem.com/products/vonoprazan.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E7004-Vonoprazan-chemical-structure.png |