Lesinurad
Lesinurad (RDEA-594) is a selective uric acid reabsorption inhibitor (SURI) under investigation for treatment of gout in combination with xanthine oxidase inhibitors. Lesinurad is a URAT1 and OAT inhibitor, is determined to be a substrate for the kidney transporters OAT1 and OAT3 with Km values of 0.85 and 2 µM, respectively.
| Trivial name | RDEA 594, RDEA-594, RDEA594 |
| Catalog Number | S4640 |
| Molecular Formula | C17H14BrN3O2S |
| CAS# | 878672-00-5 |
| Inchi | InChI=1S/C17H14BrN3O2S/c18-16-19-20-17(24-9-15(22)23)21(16)14-8-7-11(10-5-6-10)12-3-1-2-4-13(12)14/h1-4,7-8,10H,5-6,9H2,(H,22,23) |
| Inchi Key | FGQFOYHRJSUHMR-UHFFFAOYSA-N |
| SMILES | C1CC1C2=CC=C(C3=CC=CC=C23)N4C(=NN=C4Br)SCC(=O)O |
| Size | 20mg |
| Supplier Page | http://www.selleckchem.com/products/lesinurad.html |
| Additional Information | https://file.selleck.cn/downloads/struct/lesinurad-chemical-structure-s4640.gif |