ML221
ML221 is a potent apelin receptor (APJ) functional antagonist in cell-based assays that is >37-fold selective over the closely related angiotensin II type 1 (AT1) receptor. The IC50 values of ML221 are 0.70 and 1.75 μM in a cAMP assay and β-arrestin assay, respectively.
| Trivial name | N/A |
| Catalog Number | S8695 |
| Molecular Formula | C17H11N3O6S |
| CAS# | 877636-42-5 |
| Inchi | InChI=1S/C17H11N3O6S/c21-14-8-13(10-27-17-18-6-1-7-19-17)25-9-15(14)26-16(22)11-2-4-12(5-3-11)20(23)24/h1-9H,10H2 |
| Inchi Key | UASIRTUMPRQVFY-UHFFFAOYSA-N |
| SMILES | C1=CN=C(N=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=C(C=C3)[N+](=O)[O-] |
| Size | 10mg |
| Supplier Page | http://www.selleckchem.com/products/ml221.html |
| Additional Information | https://file.selleck.cn/downloads/struct/ml221-chemical-structure-s8695.gif |