Crizotinib
Crizotinib is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM in cell-based assays, respectively. It is also a potent ROS1 inhibitor with Ki value less than 0.025 nM. Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines.
| Trivial name | PF-02341066 |
| Catalog Number | S1068 |
| Molecular Formula | C5H7KO4 |
| CAS# | 877399-52-5 |
| Inchi | InChI=1S/C5H8O4.K/c1-2-9-5(8)3-4(6)7;/h2-3H2,1H3,(H,6,7);/q;+1/p-1 |
| Inchi Key | WVUCPRGADMCTBN-UHFFFAOYSA-M |
| SMILES | CCOC(=O)CC(=O)[O-].[K+] |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/PF-2341066.html |
| Additional Information | https://file.selleck.cn/downloads/struct/PF-2341066-Crizotinib-chemical-structure-S1068.gif |