Quisinostat (JNJ-26481585) 2HCl
Quisinostat (JNJ-26481585) 2HCl is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against HDACs 3, 5, 8, and 9 and lowest potency to HDACs 6 and 7. Phase 2.
| Trivial name | N/A |
| Catalog Number | S1096 |
| Molecular Formula | C21H28Cl2N6O2 |
| CAS# | 875320-31-3 |
| Inchi | InChI=1S/C21H26N6O2.2ClH/c1-26-14-17(18-4-2-3-5-19(18)26)11-22-10-15-6-8-27(9-7-15)21-23-12-16(13-24-21)20(28)25-29;;/h2-5,12-15,22,29H,6-11H2,1H3,(H,25,28);2*1H |
| Inchi Key | NRUIZESXVMJDKR-UHFFFAOYSA-N |
| SMILES | CN1C=C(C2=CC=CC=C21)CNCC3CCN(CC3)C4=NC=C(C=N4)C(=O)NO.Cl.Cl |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/JNJ-26481585.html |
| Additional Information | https://file.selleck.cn/downloads/struct/s1096-jnj26481585-chemical-structure-s1096.gif |