Ivacaftor (VX-770)
Ivacaftor (VX-770) is a selective potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM in fisher rat thyroid cells, respectively.
| Trivial name | VX-770 |
| Catalog Number | S1144 |
| Molecular Formula | C24H28N2O3 |
| CAS# | 873054-44-5 |
| Inchi | InChI=1S/C24H28N2O3/c1-23(2,3)16-11-17(24(4,5)6)20(27)12-19(16)26-22(29)15-13-25-18-10-8-7-9-14(18)21(15)28/h7-13,27H,1-6H3,(H,25,28)(H,26,29) |
| Inchi Key | PURKAOJPTOLRMP-UHFFFAOYSA-N |
| SMILES | CC(C)(C)C1=CC(=C(C=C1NC(=O)C2=CNC3=CC=CC=C3C2=O)O)C(C)(C)C |
| Size | 50mg |
| Supplier Page | http://www.selleckchem.com/products/VX-770.html |
| Additional Information | https://file.selleck.cn/downloads/struct/VX-770-chemical-structure-S1144.gif |