Trametinib (GSK1120212)
Trametinib (GSK1120212, JTP-74057) is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM in cell-free assays, no inhibition of the kinase activities of c-Raf, B-Raf, ERK1/2. Trametinib activates autophagy and induces apoptosis.
| Trivial name | JTP-74057 |
| Catalog Number | S2673 |
| Molecular Formula | C20H24N6O2S |
| CAS# | 871700-17-3 |
| Inchi | InChI=1S/C20H24N6O2S/c1-13-12-28-10-9-26(13)17-11-16(20(5-6-20)29(2,21)27)24-19(25-17)15-4-8-23-18-14(15)3-7-22-18/h3-4,7-8,11,13,21H,5-6,9-10,12H2,1-2H3,(H,22,23)/t13-,29-/m1/s1 |
| Inchi Key | OHUHVTCQTUDPIJ-JYCIKRDWSA-N |
| SMILES | CC1COCCN1C2=NC(=NC(=C2)C3(CC3)S(=N)(=O)C)C4=C5C=CNC5=NC=C4 |
| Size | 50mg |
| Supplier Page | http://www.selleckchem.com/products/gsk1120212-jtp-74057.html |
| Additional Information | https://file.selleck.cn/downloads/struct/GSK1120212-JTP-74057-chemical-structure-s2673.gif |