Trametinib (GSK1120212)

Trametinib (GSK1120212, JTP-74057) is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM in cell-free assays, no inhibition of the kinase activities of c-Raf, B-Raf, ERK1/2. Trametinib activates autophagy and induces apoptosis.

Price Not Available 10mg Trametinib (GSK1120212) Supplier Page

Trivial name	JTP-74057
Catalog Number	S2673
Molecular Formula	C26H23FIN5O4
CAS#	871700-17-3
Inchi	InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34)
Inchi Key	LIRYPHYGHXZJBZ-UHFFFAOYSA-N
SMILES	CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)NC(=O)C)C5CC5
Size	10mg
Supplier Page	http://www.selleckchem.com/products/gsk1120212-jtp-74057.html
Additional Information	https://file.selleck.cn/downloads/struct/GSK1120212-JTP-74057-chemical-structure-s2673.gif