E 2012
E 2012 is a potent gamma (γ) secretase modulator without affecting Notch processing. E 2012 inhibits 3β-hydroxysterol Δ24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E 2012 aims at Alzheimer’s disease by reduction of amyloid β-42, and induces cataract following repeated doses in the rat.
| Catalog Number | E8196 |
| Molecular Formula | C16H26O2 |
| CAS# | 870843-42-8 |
| Inchi | InChI=1S/C16H26O2/c1-14(2)7-5-8-15(3)11(14)6-9-16(4)12(15)10-13(17)18-16/h11-12H,5-10H2,1-4H3/t11-,12+,15-,16+/m0/s1 |
| Inchi Key | IMKJGXCIJJXALX-SHUKQUCYSA-N |
| SMILES | CC1(CCCC2(C1CCC3(C2CC(=O)O3)C)C)C |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/e-2012.html |
| Additional Information | https://file.selleck.cn/downloads/struct/e8196-e-2012-chemical-structure-tube.png |