Idelalisib (CAL-101)
Idelalisib (CAL-101) is a selective p110δ inhibitor with IC50 of 2.5 nM in cell-free assays; shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR. Idelalisib also stimulates autophagy.
| Trivial name | GS-1101 |
| Catalog Number | S2226 |
| Molecular Formula | C22H18FN7O |
| CAS# | 870281-82-6 |
| Inchi | InChI=1S/C22H18FN7O/c1-2-15(28-20-18-19(25-11-24-18)26-12-27-20)21-29-16-10-6-9-14(23)17(16)22(31)30(21)13-7-4-3-5-8-13/h3-12,15H,2H2,1H3,(H2,24,25,26,27,28)/t15-/m0/s1 |
| Inchi Key | IFSDAJWBUCMOAH-HNNXBMFYSA-N |
| SMILES | CCC(C1=NC2=C(C(=CC=C2)F)C(=O)N1C3=CC=CC=C3)NC4=NC=NC5=C4NC=N5 |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/CAL-101.html |
| Additional Information | https://file.selleck.cn/downloads/struct/CAL-101-chemical-structure-S2226.gif |