PF-573228
PF-573228 is an ATP-competitive inhibitor of FAK with IC50 of 4 nM in a cell-free assay, ~50- to 250-fold selective for FAK than Pyk2, CDK1/7 and GSK-3β. PF-573228 induces apoptosis.
| Trivial name | N/A |
| Catalog Number | S2013 |
| Molecular Formula | C22H20F3N5O3S |
| CAS# | 869288-64-2 |
| Inchi | InChI=1S/C22H20F3N5O3S/c1-34(32,33)16-4-2-3-13(9-16)11-26-20-17(22(23,24)25)12-27-21(30-20)28-15-6-7-18-14(10-15)5-8-19(31)29-18/h2-4,6-7,9-10,12H,5,8,11H2,1H3,(H,29,31)(H2,26,27,28,30) |
| Inchi Key | HESLKTSGTIBHJU-UHFFFAOYSA-N |
| SMILES | CS(=O)(=O)C1=CC=CC(=C1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)CC4 |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/pf-573228.html |
| Additional Information | https://file.selleck.cn/downloads/struct/PF-573228-chemical-structure-s2013.jpg |