(R)-(-)-Gossypol (AT-101) acetic acid

(R)-(-)-Gossypol (AT-101) acetic acid, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM in cell-free assays; does not inhibit BIR3 domain and BID. AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy. Phase 2.

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Catalog Number	S2812
Molecular Formula	C17H21N7O4
CAS#	866541-93-7
Inchi	InChI=1S/C17H21N7O4/c25-24(26)14-3-1-13(2-4-14)18-15-19-16(22-5-9-27-10-6-22)21-17(20-15)23-7-11-28-12-8-23/h1-4H,5-12H2,(H,18,19,20,21)
Inchi Key	MSSXBKQZZINCRI-UHFFFAOYSA-N
SMILES	C1COCCN1C2=NC(=NC(=N2)NC3=CC=C(C=C3)[N+](=O)[O-])N4CCOCC4
Size	10mg
Supplier Page	http://www.selleckchem.com/products/at101-acetic-acid.html
Additional Information	https://file.selleck.cn/downloads/struct/AT101-chemical-structure-s2812.gif