FR 180204
FR 180204 is an ATP-competitive, selective ERK inhibitor with Ki of 0.31 μM and 0.14 μM for ERK1 And ERK2, respectively. It is 30-fold less potent against the related kinase p38α and failed to inhibit any kinases(MEK1, MKK4, IKKα, PKCα, Src, Syc, and PDGFα) at less than 30 μM.
| Trivial name | N/A |
| Catalog Number | S7524 |
| Molecular Formula | C18 H13 N7 |
| CAS# | 865362-74-9 |
| Inchi | InChI=1S/C18H13N7/c19-17-12-10-13(20-22-18(12)23-21-17)15-14-8-4-5-9-25(14)24-16(15)11-6-2-1-3-7-11/h1-10H,(H3,19,21,22,23) |
| Inchi Key | XVECMUKVOMUNLE-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)C2=NN3C=CC=CC3=C2C4=CC5=C(NN=C5N=N4)N |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/fr180204.html |
| Additional Information | https://file.selleck.cn/downloads/struct/FR-180204-chemical-structure-s7524.gif |