TP0427736 HCl
TP0427736 is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50 = 836 nM for ALK3). It also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM.
| Trivial name | N/A |
| Catalog Number | S8700 |
| Molecular Formula | C14H11ClN4S2 |
| CAS# | 864374-00-5 |
| Inchi | InChI=1S/C14H10N4S2.ClH/c1-8-5-19-14(18-8)13-12(15-6-16-13)9-2-3-10-11(4-9)20-7-17-10;/h2-7H,1H3,(H,15,16);1H |
| Inchi Key | DBKPLYNIVZJPCU-UHFFFAOYSA-N |
| SMILES | CC1=CSC(=N1)C2=C(N=CN2)C3=CC4=C(C=C3)N=CS4 |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/tp0427736-hcl.html |
| Additional Information | https://file.selleck.cn/downloads/struct/tp0427736-hcl-chemical-structure-s8700.gif |