Bafetinib
Bafetinib is a potent and selective dual Bcr-Abl/Lyn inhibitor with IC50 of 5.8 nM/19 nM in cell-free assays, does not inhibit the phosphorylation of the T315I mutant and is less potent to PDGFR and c-Kit.
| Trivial name | INNO-406, NS-187 |
| Catalog Number | S1369 |
| Molecular Formula | C30H31F3N8O |
| CAS# | 859212-16-1 |
| Inchi | InChI=1S/C30H31F3N8O/c1-19-4-7-23(13-27(19)39-29-36-10-8-26(38-29)22-14-34-18-35-15-22)37-28(42)20-5-6-21(25(12-20)30(31,32)33)16-41-11-9-24(17-41)40(2)3/h4-8,10,12-15,18,24H,9,11,16-17H2,1-3H3,(H,37, 42)(H,36,38,39)/t24-/m0/s1 |
| Inchi Key | ZGBAJMQHJDFTQJ-DEOSSOPVSA-N |
| SMILES | CC1=C(C=C(C=C1)NC(=O)C2=CC(=C(C=C2)CN3CCC(C3)N(C)C)C(F)(F)F)NC4=NC=CC(=N4)C5=CN=CN=C5 |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/Bafetinib.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Bafetinib-INNO-406-chemical-structure-S1369.gif |