BML-284
BML-284 (Wnt Agonist) is a potent and cell-permeable activator of Wnt signaling that induces TCF-dependent transcriptional activity with an EC50 value of 0.7 µM. BML-284 also acts as an agonist of β-catenin that effectively activates direct Wnt-β-catenin signaling to induce adipocyte dedifferentiation while circumventing the apoptotic effect in the hypertonic treatment.
| Trivial name | Wnt Agonist |
| Catalog Number | E4800 |
| Molecular Formula | C21H22Cl2FN5O |
| CAS# | 853220-52-7 |
| Inchi | InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1 |
| Inchi Key | KTEIFNKAUNYNJU-GFCCVEGCSA-N |
| SMILES | CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/bml-284.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E4800-BML-284-chemical-structure.png |