ABT-737
ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively; no inhibition observed against Mcl-1, Bcl-B or Bfl-1. ABT-737 induces mitochondrial pathway apoptosis and mitophagy. Phase 2.
| Trivial name | N/A |
| Catalog Number | S1002 |
| Molecular Formula | C7H9NO6S |
| CAS# | 852808-04-9 |
| Inchi | InChI=1S/C7H9NO6S/c8-7(6(11)12)1-15(13,14)4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3-,4+,7+/m1/s1 |
| Inchi Key | AVDUGNCTZRCAHH-MDASVERJSA-N |
| SMILES | C1C(C2C(C2S1(=O)=O)C(=O)O)(C(=O)O)N |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/ABT-737.html |
| Additional Information | https://file.selleck.cn/downloads/struct/ABT-737-chemical-structure-S1002.gif |