Afatinib Dimaleate
Afatinib Dimaleate irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant. Afatinib (BIBW2992) Dimaleate induces autophagy.
| Trivial name | BIBW2992 Dimaleate |
| Catalog Number | S7810 |
| Molecular Formula | C24H25ClFN5O3.2C4H4O4 |
| CAS# | 850140-73-7 |
| Inchi | InChI=1S/C24H25ClFN5O3.2C4H4O4/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15;2*5-3(6)1-2-4(7)8/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H, 27,28,29);2*1-2H,(H,5,6)(H,7,8)/b4-3+;2*2-1-/t16-;;/m0../s1 |
| Inchi Key | USNRYVNRPYXCSP-JUGPPOIOSA-N |
| SMILES | CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O |
| Size | 50mg |
| Supplier Page | http://www.selleckchem.com/products/afatinib-bibw2992-dimaleate.html |
| Additional Information | https://file.selleck.cn/downloads/struct/afatinib-dimaleate-chemical-structure-s7810.gif |