Afatinib
Afatinib inhibits EGFR/ErbB irreversibly in vitro with IC50 of 0.5, 0.4, 10, 14, 1 nM for EGFRwt, EGFR L858R , EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4), respectively. Afatinib induces autophagy.
| Trivial name | BIBW2992 |
| Catalog Number | S1011 |
| Molecular Formula | C24H25ClFN5O3 |
| CAS# | 850140-72-6 |
| Inchi | InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1 |
| Inchi Key | ULXXDDBFHOBEHA-CWDCEQMOSA-N |
| SMILES | CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4 |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/BIBW2992.html |
| Additional Information | https://file.selleck.cn/downloads/struct/afatinib-bibw2992-chemical-structure-s1011.gif |