Foretinib
Foretinib is an ATP-competitive inhibitor of HGFR and VEGFR, mostly for Met (c-Met) and KDR with IC50 of 0.4 nM and 0.9 nM in cell-free assays. Less potent against Ron, Flt-1/3/4, Kit (c-Kit), PDGFRα/β and Tie-2, and little activity to FGFR1 and EGFR. Phase 2.
| Trivial name | GSK1363089, EXEL-2880, XL-880, GSK089 |
| Catalog Number | S1111 |
| Molecular Formula | C9H10O4 |
| CAS# | 849217-64-7 |
| Inchi | InChI=1S/C9H10O4/c10-7-3-1-6(5-8(7)11)2-4-9(12)13/h1,3,5,10-11H,2,4H2,(H,12,13) |
| Inchi Key | DZAUWHJDUNRCTF-UHFFFAOYSA-N |
| SMILES | C1=CC(=C(C=C1CCC(=O)O)O)O |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/XL880(GSK1363089,EXEL-2880).html |
| Additional Information | https://file.selleck.cn/downloads/struct/Foretinib-GSK1363089-XL880-chemical-structure-S1111.gif |