Foretinib
Foretinib is an ATP-competitive inhibitor of HGFR and VEGFR, mostly for Met (c-Met) and KDR with IC50 of 0.4 nM and 0.9 nM in cell-free assays. Less potent against Ron, Flt-1/3/4, Kit (c-Kit), PDGFRα/β and Tie-2, and little activity to FGFR1 and EGFR. Phase 2.
| Trivial name | GSK1363089, EXEL-2880, XL-880, GSK089 |
| Catalog Number | S1111 |
| Molecular Formula | C34H34F2N4O6 |
| CAS# | 849217-64-7 |
| Inchi | InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2 ,1H3,(H,38,41)(H,39,42) |
| Inchi Key | CXQHYVUVSFXTMY-UHFFFAOYSA-N |
| SMILES | COC1=CC2=C(C=CN=C2C=C1OCCCN3CCOCC3)OC4=C(C=C(C=C4)NC(=O)C5(CC5)C(=O)NC6=CC=C(C=C6)F)F |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/XL880(GSK1363089,EXEL-2880).html |
| Additional Information | https://file.selleck.cn/downloads/struct/Foretinib-GSK1363089-XL880-chemical-structure-S1111.gif |