Foretinib
Foretinib is an ATP-competitive inhibitor of HGFR and VEGFR, mostly for Met (c-Met) and KDR with IC50 of 0.4 nM and 0.9 nM in cell-free assays. Less potent against Ron, Flt-1/3/4, Kit (c-Kit), PDGFRα/β and Tie-2, and little activity to FGFR1 and EGFR. Phase 2.
| Trivial name | GSK1363089, EXEL-2880, XL-880, GSK089 |
| Catalog Number | S1111 |
| Molecular Formula | C28H17N5Na4O14S4 |
| CAS# | 849217-64-7 |
| Inchi | InChI=1S/C28H21N5O14S4.4Na/c1-14(34)29-23-10-11-24(50(42,43)44)20-13-25(51(45,46)47)27(28(35)26(20)23)33-32-22-9-8-21(18-7-6-17(12-19(18)22)49(39,40)41)31-30-15-2-4-16(5-3-15)48(36,37)38;;;;/h2-13,35H ,1H3,(H,29,34)(H,36,37,38)(H,39,40,41)(H,42,43,44)(H,45,46,47);;;;/q;4*+1/p-4/b31-30-,33-32+;;;; |
| Inchi Key | GMMAPXRGRVJYJY-OXYXOBGMSA-J |
| SMILES | CC(=O)NC1=C2C(=C(C=C1)S(=O)(=O)[O-])C=C(C(=C2O)N=NC3=C4C=C(C=CC4=C(C=C3)N=NC5=CC=C(C=C5)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-].[Na+].[Na+].[Na+].[Na+] |
| Size | 50mg |
| Supplier Page | http://www.selleckchem.com/products/XL880(GSK1363089,EXEL-2880).html |
| Additional Information | https://file.selleck.cn/downloads/struct/Foretinib-GSK1363089-XL880-chemical-structure-S1111.gif |