Sapitinib (AZD8931)
Sapitinib (AZD8931) is a reversible, ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 with IC50 of 4 nM, 3 nM and 4 nM in cell-free assays, more potent against NSCLC cell, 100-fold more selective for the ErbB family than MNK1 and Flt. Phase 2.
| Trivial name | N/A |
| Catalog Number | S2192 |
| Molecular Formula | C23H21IN2O3 |
| CAS# | 848942-61-0 |
| Inchi | InChI=1S/C23H21IN2O3/c24-18-11-12-20(19(14-18)23(28)29)26-22(27)21(13-16-7-3-1-4-8-16)25-15-17-9-5-2-6-10-17/h1-12,14,21,25H,13,15H2,(H,26,27)(H,28,29)/t21-/m0/s1 |
| Inchi Key | IRDIXDXDSUBHIU-NRFANRHFSA-N |
| SMILES | C1=CC=C(C=C1)CC(C(=O)NC2=C(C=C(C=C2)I)C(=O)O)NCC3=CC=CC=C3 |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/AZD8931.html |
| Additional Information | https://file.selleck.cn/downloads/struct/AZD8931-chemical-structure-S2192.gif |