Sapitinib (AZD8931)
Sapitinib (AZD8931) is a reversible, ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 with IC50 of 4 nM, 3 nM and 4 nM in cell-free assays, more potent against NSCLC cell, 100-fold more selective for the ErbB family than MNK1 and Flt. Phase 2.
| Trivial name | N/A |
| Catalog Number | S2192 |
| Molecular Formula | C29H27F5N2O5S |
| CAS# | 848942-61-0 |
| Inchi | InChI=1S/C29H27F5N2O5S/c1-35(42(40,41)28-26(33)24(31)23(30)25(32)27(28)34)16-22(37)36(21-13-11-20(12-14-21)29(38)39)15-17-7-9-19(10-8-17)18-5-3-2-4-6-18/h7-14,18H,2-6,15-16H2,1H3,(H,38,39) |
| Inchi Key | VFPYGNNOSJWBHF-UHFFFAOYSA-N |
| SMILES | CN(CC(=O)N(CC1=CC=C(C=C1)C2CCCCC2)C3=CC=C(C=C3)C(=O)O)S(=O)(=O)C4=C(C(=C(C(=C4F)F)F)F)F |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/AZD8931.html |
| Additional Information | https://file.selleck.cn/downloads/struct/AZD8931-chemical-structure-S2192.gif |