RO4929097
RO4929097 (RG-4733) is a γ secretase inhibitor with IC50 of 4 nM in a cell-free assay, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respectively. Phase 2.
| Trivial name | RG-4733 |
| Catalog Number | S1575 |
| Molecular Formula | C22H20F5N3O3 |
| CAS# | 847925-91-1 |
| Inchi | InChI=1S/C22H20F5N3O3/c1-20(2,18(32)28-11-21(23,24)22(25,26)27)19(33)30-16-14-9-4-3-7-12(14)13-8-5-6-10-15(13)29-17(16)31/h3-10,16H,11H2,1-2H3,(H,28,32)(H,29,31)(H,30,33)/t16-/m0/s1 |
| Inchi Key | OJPLJFIFUQPSJR-INIZCTEOSA-N |
| SMILES | CC(C)(C(=O)NCC(C(F)(F)F)(F)F)C(=O)NC1C2=CC=CC=C2C3=CC=CC=C3NC1=O |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/RO4929097.html |
| Additional Information | https://file.selleck.cn/downloads/struct/RO4929097-chemical-structure-S1575.gif |