Itraconazole
Itraconazole is a relatively potent inhibitor of CYP3A4 with IC50 of 6.1 nM, used as a triazole antifungal agent. Itraconazole is a potent antagonist of the Hedgehog (Hh) signaling pathway. Itraconazole suppresses the growth of glioblastoma through induction of autophagy.
| Trivial name | R 51211 |
| Catalog Number | S2476 |
| Molecular Formula | C35H38Cl2N8O4 |
| CAS# | 84625-61-6 |
| Inchi | InChI=1S/C35H38Cl2N8O4/c1-3-25(2)45-34(46)44(24-40-45)29-7-5-27(6-8-29)41-14-16-42(17-15-41)28-9-11-30(12-10-28)47-19-31-20-48-35(49-31,21-43-23-38-22-39-43)32-13-4-26(36)18-33(32)37/h4-13,18,22-25,31 H,3,14-17,19-21H2,1-2H3/t25?,31-,35-/m0/s1 |
| Inchi Key | VHVPQPYKVGDNFY-ZPGVKDDISA-N |
| SMILES | CCC(C)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OCC5COC(O5)(CN6C=NC=N6)C7=C(C=C(C=C7)Cl)Cl |
| Size | 200mg |
| Supplier Page | http://www.selleckchem.com/products/Itraconazole(Sporanox).html |
| Additional Information | https://file.selleck.cn/downloads/struct/Itraconazole-Sporanox-chemical-structure-S2476.gif |