AT7519
AT7519 is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9 with IC50 of 10-210 nM. It is less potent to CDK3 and little active to CDK7. AT7519 also decrease GSK3β phosphorylation. AT7519 induces apoptosis. Phase 2.
| Trivial name | AT7519M |
| Catalog Number | S1524 |
| Molecular Formula | C16H17Cl2N5O2 |
| CAS# | 844442-38-2 |
| Inchi | InChI=1S/C16H17Cl2N5O2/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24) |
| Inchi Key | OVPNQJVDAFNBDN-UHFFFAOYSA-N |
| SMILES | C1CNCCC1NC(=O)C2=C(C=NN2)NC(=O)C3=C(C=CC=C3Cl)Cl |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/AT7519.html |
| Additional Information | https://file.selleck.cn/downloads/struct/AT7519-chemical-structure-S1524.gif |