Bedaquiline
Bedaquiline (TMC-207, R207910), a diarylquinoline, binds to subunit c of mycobacterial ATP synthase and inhibits its activity. It is highly selective for mycobacterial ATP synthase enzyme compared to homologous eukaryotic enzyme (Selectivity Index >20 000).
| Trivial name | TMC-207, R207910 |
| Catalog Number | S5623 |
| Molecular Formula | C32H31BrN2O2 |
| CAS# | 843663-66-1 |
| Inchi | InChI=1S/C32H31BrN2O2/c1-35(2)19-18-32(36,28-15-9-13-22-10-7-8-14-26(22)28)30(23-11-5-4-6-12-23)27-21-24-20-25(33)16-17-29(24)34-31(27)37-3/h4-17,20-21,30,36H,18-19H2,1-3H3/t30-,32-/m1/s1 |
| Inchi Key | QUIJNHUBAXPXFS-XLJNKUFUSA-N |
| SMILES | CN(C)CCC(C1=CC=CC2=CC=CC=C21)(C(C3=CC=CC=C3)C4=C(N=C5C=CC(=CC5=C4)Br)OC)O |
| Size | 10mg |
| Supplier Page | http://www.selleckchem.com/products/bedaquiline.html |
| Additional Information | https://file.selleck.cn/downloads/struct/bedaquiline-chemical-structure-s5623.gif |