R406 (free base)
R406 (free base) is a potent Syk inhibitor with IC50 of 41 nM in a cell-free assay, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. R406 (free base) triggers apoptosis. Phase 1.
| Trivial name | N/A |
| Catalog Number | S1533 |
| Molecular Formula | C22H23FN6O5 |
| CAS# | 841290-80-0 |
| Inchi | InChI=1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30) |
| Inchi Key | NHHQJBCNYHBUSI-UHFFFAOYSA-N |
| SMILES | CC1(C(=O)NC2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)C |
| Size | 10mg |
| Supplier Page | http://www.selleckchem.com/products/R406(free-base).html |
| Additional Information | https://file.selleck.cn/downloads/struct/R406-free-base-chemical-structure-S1533.gif |