GNF-6 | MedChemExpress (MCE)
GNF-6 (Compound 14) inhibits the gatekeeper threonine residue mutation of BCR-ABL-T315I with IC50s of 0.25 μM, 0.09 μM and 0.590 μM for c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants, respectively. GNF-6, an ATP competitive inhibitor, disrupts the assembly of the hydrophobic spine (a network of hydrophobic interactions), thereby locking the kinase in an inactive ‘DFG-out’ conformation[1].
| Trivial name | GNF-6 |
| Catalog Number | HY-160478 |
| Research Area | Cancer |
| CAS# | 839708-29-1 |
| Purity | ≥98.0% |
| SMILES | O=C(C1=CC=CC(C(F)(F)F)=C1)NC2=CC=C(C)C(N3C(N(C)C4=NC(N)=NC=C4C3)=O)=C2 |
| Size | 1 mg |
| Supplier Page | https://www.medchemexpress.com/gnf-6.html |