MAC-545496
MAC-545496 is a nanomolar glycopeptide-resistance-associated protein R(GraR) inhibitor with strong binding affinity to the full-length GraR protein (Kd ≤ 0.1 nM). MAC-545496 can reverse β-lactam resistance in methicillin-resistant strains and synergize with CAMPs. MAC-545496 shows remarkable activity in macrophages and attenuates S. aureus virulence in a G. mellonella larvae infection model.
| Trivial name | N/A |
| Catalog Number | S6771 |
| Molecular Formula | C18H18ClN5O3S |
| CAS# | 838810-96-1 |
| Inchi | InChI=1S/C18H18ClN5O3S/c19-13-5-7-16(20-11-13)21-18(28)22-17(25)12-4-6-14(15(10-12)24(26)27)23-8-2-1-3-9-23/h4-7,10-11H,1-3,8-9H2,(H2,20,21,22,25,28) |
| Inchi Key | AFOKREIUUQFDNW-UHFFFAOYSA-N |
| SMILES | C1CCN(CC1)C2=C(C=C(C=C2)C(=O)NC(=S)NC3=NC=C(C=C3)Cl)[N+](=O)[O-] |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/mac-545496.html |
| Additional Information | https://file.selleck.cn/downloads/struct/mac-545496-chemical-structure-s6771.gif |