WH-4-023
WH-4-023 (KIN001-112, KIN112, Dual LCK/SRC inhibitor) is a potent and orally active Lck/Src inhibitor withIC50s of 2 nM and 6 nM in cell-free assays, respectively. Exhibits >300-fold selectivity against p38α and KDR. Also potently inhibits SIK (IC50 values are 10, 22 and 60 nM for SIK 1, 2 and 3 respectively) and displays selectivity over a range of closely related kinases.
| Trivial name | KIN001-112, KIN112, Dual LCK/SRC inhibitor |
| Catalog Number | S7565 |
| Molecular Formula | C32H36N6O4 |
| CAS# | 837422-57-8 |
| Inchi | InChI=1S/C32H36N6O4/c1-22-7-6-8-23(2)30(22)42-32(39)38(27-14-13-26(40-4)21-28(27)41-5)29-15-16-33-31(35-29)34-24-9-11-25(12-10-24)37-19-17-36(3)18-20-37/h6-16,21H,17-20H2,1-5H3,(H,33,34,35) |
| Inchi Key | NBTNHSGBRGTFJS-UHFFFAOYSA-N |
| SMILES | CC1=C(C(=CC=C1)C)OC(=O)N(C2=C(C=C(C=C2)OC)OC)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCN(CC5)C |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/wh-4-023.html |
| Additional Information | https://file.selleck.cn/downloads/struct/WH-4-023-chemical-structure-s7565.gif |