Danusertib (PHA-739358)

Danusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM in cell-free assays, modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc. Danusertib induces apoptosis, cell cycle arrest, and autophagy. Phase 2.

Price Not Available 5mg Danusertib (PHA-739358) Supplier Page

Trivial name	N/A
Catalog Number	S1107
Molecular Formula	C26H30N6O3
CAS#	827318-97-8
Inchi	InChI=1S/C26H30N6O3/c1-30-12-14-31(15-13-30)20-10-8-19(9-11-20)25(33)27-24-21-16-32(17-22(21)28-29-24)26(34)23(35-2)18-6-4-3-5-7-18/h3-11,23H,12-17H2,1-2H3,(H2,27,28,29,33)/t23-/m1/s1
Inchi Key	XKFTZKGMDDZMJI-HSZRJFAPSA-N
SMILES	CN1CCN(CC1)C2=CC=C(C=C2)C(=O)NC3=NNC4=C3CN(C4)C(=O)C(C5=CC=CC=C5)OC
Size	5mg
Supplier Page	http://www.selleckchem.com/products/PHA-739358(Danusertib).html
Additional Information	https://file.selleck.cn/downloads/struct/Danusertib-PHA-739358-chemical-structure-S1107.gif