Danusertib (PHA-739358)
Danusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM in cell-free assays, modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc. Danusertib induces apoptosis, cell cycle arrest, and autophagy. Phase 2.
| Trivial name | N/A |
| Catalog Number | S1107 |
| Molecular Formula | C10H15N5O10P2.xNa |
| CAS# | 827318-97-8 |
| SMILES | C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)([O-])OP(=O)([O-])[O-])O)O)N.[Na+].[Na+].[Na+] |
| Size | 50mg |
| Supplier Page | http://www.selleckchem.com/products/PHA-739358(Danusertib).html |
| Additional Information | https://file.selleck.cn/downloads/struct/Danusertib-PHA-739358-chemical-structure-S1107.gif |