Cilastatin sodium
Cilastatin sodium (MK0791 sodium) is a reversible, competitive inhibitor of renal dehydropeptidase I (also known as membrane dipeptidase, MDP), with an IC50 of 0.1 µM. It is primarily used in combination with imipenem to enhance the antibiotic’s effectiveness against a broad spectrum of bacterial infections by preventing its degradation in the kidneys.
| Trivial name | MK0791 sodium |
| Catalog Number | E6033 |
| Molecular Formula | C16H18FN3O3 |
| CAS# | 81129-83-1 |
| Inchi | InChI=1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23) |
| Inchi Key | OGJPXUAPXNRGGI-UHFFFAOYSA-N |
| SMILES | CCN1C=C(C(=O)C2=CC(=C(C=C21)N3CCNCC3)F)C(=O)O |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/cilastatin-sodium.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E6033-Cilastatin-sodium-chemical-structure.png |
