Simethicone is an orally active defoamer. Simethicone reduces the surface tension of air bubbles in the gastrointestinal tract, causing them to be expelled by vomiting, exhalation or absorption into the bloodstream. Simethicone has potential applications in flatulence and colic.In Vivo:Simethicone (200 mg/kg; p.o.; single dose) has gastrointestinal regulation function in rats[2].
Simethicone (20 mg/kg; p.o.; single dose) shows jejunal regulation in rabbits.