Silybin is a flavonolignan isolated from milk thistle (Silybum marianum) seeds. Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity[2].In Vitro: Silybin (0-200 mM; for 72 hours) has growth inhibition in a time- and dose-dependent manner.
Silybin (68 μM; for 72 hours) induces apoptosis and increases the cells in G1-phase of ~22%.
Silybin (68 μM; for 72 hours) induces AKT activity inhibition.
In Vivo: Silybin (50, 100?mg/kg/day; given intragastrically for the last 4 weeks) significantly lowers both serum and hepatic lipid accumulation[2].