Milciclib
Milciclib is a potent, ATP-competitive CDK inhibitor for CDK2 with IC50 of 45 nM. It is >3-fold more selective for CDK2 than CDK1, 2, 4, 5, and 7, it’s also an inhibitor of TRKA with IC50 of 53nM. Milciclib (PHA-848125) induces cell death through autophagy. Phase 2.
| Trivial name | PHA-848125 |
| Catalog Number | S2751 |
| Molecular Formula | C24H29FN6O5 |
| CAS# | 802539-81-7 |
| Inchi | InChI=1S/C21H21FN6O.C3H6O3/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29;1-2(4)3(5)6/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29);2,4H,1H3,(H,5,6) |
| Inchi Key | ZRHDKBOBHHFLBW-UHFFFAOYSA-N |
| SMILES | CC(C(=O)O)O.CN1CCN(CC1)C2=CC3=C(C=C2)N=C(N3)C4=C(C5=C(C=CC=C5F)NC4=O)N.O |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/pha-848125.html |
| Additional Information | https://file.selleck.cn/downloads/struct/PHA-848125-chemical-structure-s2751.gif |