LCH-7749944
LCH-7749944 (GNF-PF-2356) is a novel and potent p21-activated kinase 4 (PAK4) inhibitor with an IC50 of 14.93 μM and has less potently inhibitory effect against PAK1, PAK5 and PAK6. LCH-7749944 causes successful inhibition of EGFR activity due to its inhibitory effect on PAK4.
| Trivial name | GNF-PF-2356 |
| Catalog Number | S1976 |
| Molecular Formula | C22H22ClN5O2 |
| CAS# | 796888-12-5 |
| Inchi | InChI=1S/C22H22ClN5O2/c1-4-24-20(29)12-18-22-27-26-13(2)28(22)19-10-9-16(30-3)11-17(19)21(25-18)14-5-7-15(23)8-6-14/h5-11,18H,4,12H2,1-3H3,(H,24,29)/t18-/m0/s1 |
| Inchi Key | AAAQFGUYHFJNHI-SFHVURJKSA-N |
| SMILES | CCNC(=O)CC1C2=NN=C(N2C3=C(C=C(C=C3)OC)C(=N1)C4=CC=C(C=C4)Cl)C |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/lch-7749944.html |
| Additional Information | https://file.selleck.cn/downloads/struct/s1976-lch-7749944-chemical-structure.gif |