YM155 (Sepantronium Bromide)

YM155 (Sepantronium Bromide) is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM in HeLa-SURP-luc and CHO-SV40-luc cells; does not significantly inhibit SV40 promoter activity, but is observed to slightly inhibit the interaction of Survivin with XIAP. YM155 down-regulates survivin and XIAP, modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells. Phase 2.

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Trivial name	N/A
Catalog Number	S1130
Molecular Formula	C20H19BrN4O3
CAS#	781661-94-7
Inchi	InChI=1S/C20H19N4O3.BrH/c1-13-23(9-10-27-2)17-18(24(13)12-14-11-21-7-8-22-14)20(26)16-6-4-3-5-15(16)19(17)25;/h3-8,11H,9-10,12H2,1-2H3;1H/q+1;/p-1
Inchi Key	QBIYUDDJPRGKNJ-UHFFFAOYSA-M
SMILES	CC1=[N+](C2=C(N1CCOC)C(=O)C3=CC=CC=C3C2=O)CC4=NC=CN=C4.[Br-]
Size	10mg
Supplier Page	http://www.selleckchem.com/products/YM155.html
Additional Information	https://file.selleck.cn/downloads/struct/YM155-chemical-structure-s1130.gif