Dinaciclib
Dinaciclib is a novel and potent CDK inhibitor for CDK2, CDK5, CDK1 and CDK9 with IC50 of 1 nM, 1 nM, 3 nM and 4 nM in cell-free assays, respectively. It also blocks thymidine (dThd) DNA incorporation. Dinaciclib induces apoptosis through the activation of caspases 8 and 9. Phase 3.
| Trivial name | SCH727965, PS-095760 |
| Catalog Number | S2768 |
| Molecular Formula | C19H21N3O3S |
| CAS# | 779353-01-4 |
| Inchi | InChI=1S/C19H21N3O3S/c1-22(2)26(24,25)14-7-8-18-15(11-14)16(19(23)21-18)10-13-9-12-5-3-4-6-17(12)20-13/h7-11,20H,3-6H2,1-2H3,(H,21,23)/b16-10- |
| Inchi Key | LOGJQOUIVKBFGH-YBEGLDIGSA-N |
| SMILES | CN(C)S(=O)(=O)C1=CC2=C(C=C1)NC(=O)C2=CC3=CC4=C(N3)CCCC4 |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/dinaciclib-sch727965.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Dinaciclib(SCH-727965)-chemical-structure-s2768.gif |