Olaparib (AZD2281)

Olaparib (AZD2281, KU0059436) is a selective inhibitor of PARP1/2 with IC50 of 5 nM/1 nM in cell-free assays, 300-times less effective against tankyrase-1. Olaparib induces significant autophagy that is associated with mitophagy in cells with BRCA mutations.

Price Not Available 10mM/1mL Olaparib (AZD2281) Supplier Page

Trivial name	Ku-0059436
Catalog Number	S1060
Molecular Formula	C24H23FN4O3
CAS#	763113-22-0
Inchi	InChI=1S/C24H23FN4O3/c25-20-8-5-15(14-21-17-3-1-2-4-18(17)22(30)27-26-21)13-19(20)24(32)29-11-9-28(10-12-29)23(31)16-6-7-16/h1-5,8,13,16H,6-7,9-12,14H2,(H,27,30)
Inchi Key	FDLYAMZZIXQODN-UHFFFAOYSA-N
SMILES	C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F
Size	10mM/1mL
Supplier Page	http://www.selleckchem.com/products/AZD2281(Olaparib).html
Additional Information	https://file.selleck.cn/downloads/struct/Olaparib-AZD2281-chemical-structure-S1060.gif