TAE684 (NVP-TAE684)
TAE684 (NVP-TAE684) is a potent and selective ALK inhibitor which blocked the growth of ALCL-derived and ALK-dependent cell lines with IC50 values between 2 and 10 nM, 100-fold more sensitive for ALK than InsR. TAE684 (NVP-TAE684) induces cell cycle arrest and apoptosis.
Trivial name | N/A |
Catalog Number | S1108 |
Molecular Formula | C30H40ClN7O3S |
CAS# | 761439-42-3 |
Inchi | InChI=1S/C30H40ClN7O3S/c1-21(2)42(39,40)28-8-6-5-7-26(28)33-29-24(31)20-32-30(35-29)34-25-10-9-23(19-27(25)41-4)37-13-11-22(12-14-37)38-17-15-36(3)16-18-38/h5-10,19-22H,11-18H2,1-4H3,(H2,32,33,34,35) |
Inchi Key | QQWUGDVOUVUTOY-UHFFFAOYSA-N |
SMILES | CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)OC |
Size | 5mg |
Supplier Page | http://www.selleckchem.com/products/NVP-TAE684.html |
Additional Information | https://file.selleck.cn/downloads/struct/TAE684-chemical-structure-S1108.gif |