Tanespimycin (17-AAG)

Tanespimycin (17-AAG, CP127374, NSC-330507, KOS 953) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Tanespimycin (17-AAG) induces apoptosis, necrosis, autophagy and mitophagy. Phase 3.

Price Not Available 10mM/1mL Tanespimycin (17-AAG) Supplier Page

Trivial name	CP127374, NSC-330507, KOS 953
Catalog Number	S1141
Molecular Formula	C31H43N3O8
CAS#	75747-14-7
Inchi	InChI=1S/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-11,15-17,19,24-25,27,29,33,36H,1,12-14H2,2-7H3,(H2,32 ,39)(H,34,38)/b11-9-,18-10+,20-15+/t17-,19+,24+,25+,27-,29+/m1/s1
Inchi Key	AYUNIORJHRXIBJ-TXHRRWQRSA-N
SMILES	CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)C)C)O)OC
Size	10mM/1mL
Supplier Page	http://www.selleckchem.com/products/17-AAG(Geldanamycin).html
Additional Information	https://file.selleck.cn/downloads/struct/17-AAG-Geldanamycin-chemical-structure-S1141.gif