Volasertib
Volasertib is a highly potent Plk1 inhibitor with IC50 of 0.87 nM in a cell-free assay. It shows 6- and 65-fold greater selectivity against Plk2 and Plk3. Volasertib induces cell cycle arrest and apoptosis in various cancer cells. Phase 3.
| Trivial name | BI 6727 |
| Catalog Number | S2235 |
| Molecular Formula | C34H50N8O3 |
| CAS# | 755038-65-4 |
| Inchi | InChI=1S/C34H50N8O3/c1-6-28-33(44)39(4)29-20-35-34(38-31(29)42(28)22(2)3)37-27-14-9-24(19-30(27)45-5)32(43)36-25-10-12-26(13-11-25)41-17-15-40(16-18-41)21-23-7-8-23/h9,14,19-20,22-23,25-26,28H,6-8,10- 13,15-18,21H2,1-5H3,(H,36,43)(H,35,37,38)/t25-,26-,28-/m1/s1 |
| Inchi Key | SXNJFOWDRLKDSF-STROYTFGSA-N |
| SMILES | CCC1C(=O)N(C2=CN=C(N=C2N1C(C)C)NC3=C(C=C(C=C3)C(=O)NC4CCC(CC4)N5CCN(CC5)CC6CC6)OC)C |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/BI6727-Volasertib.html |
| Additional Information | https://file.selleck.cn/downloads/struct/BI6727-Volasertib-chemical-structure-S2235.gif |